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Alpha-lipoic acid ( There is already substantial experimental
and clinical evidence to show that To deliver Pale yellow crystalline powder of ALA 10.0, 29.2 and 44.4 g were mixed well with 20.0 g of Neusilin® US2 and other excipients as shown in table below. The mixture, after sieving through a 30 mesh screen, was compressed into 250 mg tablets on a single punch rotary tabletting machine (Sankyo Piotech). The ALA- Neusilin® mix did not show any stickiness or problems with flowability during the tablet manufacturing process. Disintegration test was carried as per JP in water at 37°C and the tablets showed fast disintegration with increased load of ALA. |
Formulation summary of alpha lipoic acid tablets with Neusilin®and other excipients |
*Tablets manufactured on a Rotary tabletting machine. |
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Conclusion |
High quality directly compressed tablets
of alpha lipoic acid with a load of up to 45% was possible when Neusilin® US2 was used as
excipient. |
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Chemical
formula: Al203.MgO.1.7SiO2.xH2O |
References |
To obtain a sample
or to find your local distributor, please contact us at pharma@fujichemical.co.jp.
For more technical information, please visit www.fujichemical.co.jp/english/neusilin.html |
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