Greetings! 
 
Welcome. This issue of Fuji's newsletter presents oil adsorption capacity of Fujicalin® and compare it with other available DCPA's.
 
Oil adsorption capacity of Fujicalin® and other commercially available DCPA's
Converting oily actives into a free flowing powder which then can be processed into capsules or tablets is a great challenge for formulators in Pharma, Nutra and Cosmetic industries. Although silicates and other ingredients such as microcrystalline cellulose, maltodextrin have been recommended for oil adsorption, the oil load affects flowability, compactability and compressibility leading to poor quality tablets.
 
Fuji Chemical offers two unique excipients, Neusilin® a magnesium aluminometasilcate and Fujicalin®, a dibasic calcium phosphate anhydrous (DCPA) to develop free flowing powders of oily actives that has excellent tablettability. In this newsletter, we compare the oil adsorbent properties and tablettability of Fujicalin® to that of other available DCPA's.
Fig1Boiled linseed oil is used as a surface coating material alone or in oil based paints. It is the recommended oil for testing oil adsorption properties according to Japanese Industrial Standards (JIS K5101). High quality tablets with sufficient hardness and disintegration times were possible with Fujicalin® where as other DCPA's produced softer tablets (Table 1, Figure 1). Fujicalin® showed excellent compressibility achieving optimum tablet hardness of 80 to 100 N at very low compression forces (6-8 kN).
 
 
Table 1. Boiled linseed oil adsorption capacity of Fujicalin® and other commercially available DCPA's 

Table 1 
 
Oil to Powder- Boiled Linseed oil example: 
12.5 g of boiled linseed oil was diluted with the same amount of ethanol and mixed well before loading on to 83.5 g Fujicalin® or other available grades of DCPA. The mixture was dried in an oven at 50C overnight. 3 g Croscarmellose sodium and 1 g Mg-stearate was added to the formulation and the mixture was sieved through a 30 mesh screen. Tabletting was carried out in a single punch tabletting machine (Sankyo Piotech) at 5, 10 and 15 kN.
 
SEM Photomicrographs:
The SEM photomicrographs capture the physical status of Fujicalin® and another Japanese grade DCPA. Fujicalin® maintains its original physical structure even after adsorption of boiled linseed oil and allows the preparation of harder, compact, high quality tablets without any oil extrusion. On the contrary, the DCPA Japanese grade appears very sticky after oil adsorption. This results in poor flowability and softer, inferior quality tablets.Fujicalin SEM
 
Conclusions:
Fujicalin® is spherically granulated, has lower mean particle size and extremely high specific surface area when compared to other available DCPA and Dibasic Calcium Phosphate Dihydrate (DCPD). Among the DCPA's tested, Fujicalin® showed superior tabletting properties after boiled linseed oil adsorption. Fujicalin® was the best performer giving highest tablet hardness at low compression forces. This could also help extend the life of punches and dyes by protecting them from abrasion. Adsorption of Vitamin E at 13 to 15% load on to Fujicalin® and other DCPA's showed similar results to that of boiled linseed oil. Further investigation for optimum oil load that can be processed into hard capsules will be of immediate future interest. 
 
Dosage and Safety:
Fujicalin® is manufactured under strict quality control at our FDA-GMP certified facilities. Dibasic calcium phosphate anhydrous is widely used in oral pharmaceutical products and food products. It is generally regarded as relatively nontoxic and nonirritant material. 
Fujicalin®:
Chemical formula : CaHPO4
Chemical Abstract Service (CAS) Number: 7757-93-9
U.S. Patent No. 5,486,365, Jan 1996
U.S. Drug Master File (DMF) filed, Conforms to USP/NF, EP and JP; and listed as GRAS
Fujicalin is a trademark or registered trademark of Fuji Chemical Industry Co., Ltd in Japan, United States of America, Europe and/or other countries. 
To obtain a sample or to find your local distributor, please contact us.
 For more technical information on Fujicalin®, click here
To read Fuji's technical newsletter back numbers, click here
 
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The information found in this publication is presented in good faith with no guarantee or obligation as to accuracy and no assumption of liability. Users should make their own tests to determine the suitability of these products for their own particular purposes. However, because of numerous factors affecting results, Fuji Chemical Industry makes no warranty of any kind, express or implied, including those of merchantability and fitness for particular purpose other than the material conforms to its applicable current standard specifications. Statements concerning the use of the products or formulations described herein are not to be construed as recommending the infringement of any patent and seller assumes no liability for the infringement arising out of such use. 
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