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Neusilin® is a synthetic, amorphous form of Magnesium
Aluminometasilicate and has been in the Japanese market for more than 50
years. |
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PROPERTY |
Grade S1 |
Grade FH2 |
Grade US2 |
Grade ULF2 |
Loss on Drying (%) |
16.0 |
2.8 |
1.4 |
1.8 |
Bulk Density - Loose (g/ml) |
0.33 |
0.31 |
0.15 |
0.08 |
Bulk Density - Tapped (g/ml) |
0.40 |
0.43 |
0.19 |
0.13 |
True Specific Gravity (g/ml) |
2.0 |
2.2 |
2.2 |
2.2 |
BET Specific Surface Area (m2/g) |
110 |
110 |
300 |
300 |
Mean Particle Size (ìm) (Agglomerate) |
70 - 110 |
10 - 20 |
60 - 120 |
2 - 8 |
Angle of Repose (Degrees) |
30 |
45 |
30 |
45 |
Oil Adsorbing Capacity (ml/g) |
1.3 |
1.5 |
3.2 |
3.2 |
pH of 5% Slurry |
9.4 |
9.7 |
7.4 |
7.4 |
Packaging (Kg) |
20 |
10 |
10 |
5 |
The grades US2 and UFL2 have large specific surface area which helps adsorb oils up to three times its own weight. In addition, these grades give you better flowability and harder tablets at low compression force. Unlike traditional Magnesium Aluminum Silicates, where the pH is alkaline, US2 and UFL2 is neutral giving you a broader API compatibility. The following figures illustrates the Neusilin® advantage in solving problems with oily actives. |
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Oil adsorption capacity: Neusilin US2 and UFL2 grades show higher oil adsorption capacity when compared to MCC or Colloidal silica |
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An ethanol solution of tocopherol acetate (VE) 20-50% was compounded with proportional amount of Neusilin and mixed well. To this mixture, 3% Croscarmellose sodium and 1% Magensium stearate was added before tabletting. High qulaity tablets with a load of up to 30% Vitamin E can be prepared with Neusilin US2. |
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A mixture containing 25% Scopolia extract or Soybean oil and 25% UFL2 was compounded with equal amount of Lactose. This mixture was subjected to static compression and tabletting. There was no adhesion to pestle and mortar and the compressibility was good. The tablets did not exude extract or oil under compresson or during storage. |
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Tablet hardness of cornstarch/lactose based tablets compounded with either using Neusilin US2, colloidal silica or calcium silicate. Corn starch, lactose and excipient were mixed thoroughly. Magnesium stearate as lubricant was added prior to tabletting. Compression with Neusilin US2 generally gives harder tablets compared to colloidal silica. |
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Improving angle of repose of potato
starch: Comparison with Neusilin UFL2, colloidal silica and calcium
silicate. |
These highlights are just a few of the
multifunctional properties that make Neusilin®
your ideal excipient to produce high quality tablets containing oily actives. |
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