The Astaxanthin of Choice AstaREAL®, AstaTROL®
Astaxanthin – Carotenoid Xanthophyll
- Natural astaxanthin manufactured and marketed by Fuji is not just another antioxidant. This powerful ingredient is marketed worldwide under the bulk trade names AstaREAL® and AstaTROL®.
Presently, several ground-breaking human clinical trials and research studies provided evidence to support the fact that astaxanthin is the strongest antioxidant available with exceptional properties that rivals most popular antioxidants on the market today. These should be the primary reasons for natural astaxanthin to become part of your daily nutritional supplementation or anti-aging program so that you are protected against the barrage of oxidative stress of today's world and aging process.
Presence in Nature
Astaxanthin is a natural carotenoid found in abundance from the artic marine environments to the common rock pool. Astaxanthin is what gives the pink and red colour to the flesh of salmon, shrimps and lobster. However, animals depend on their diet to obtain astaxanthin and other carotenoids since they can not produce carotenoids by themselves. Astaxanthin is produced de novo in nature by algae, some fungi, bacteria and very few higher plants.
Nature's Power to Human Life
In nature, the highest concentration is found in the green unicellular alga Haematococcus pluvialis where the astaxanthin content can be as high as 7 % of the dry weight. Lying unassumingly at the bottom of the food chain, single-cell microalgae plants take energy from the sun and combine it with organic resources to produce nearly all living material and food on earth. In the alga, astaxanthin is accumulated in lipid vesicles during times of nutrient deficiency and environmental stress. Astaxanthin functions to protect the cell nucleus against UV induced oxidative stress that would otherwise damage its DNA and energy resevoirs that undergo lipid peroxidation.
Astaxanthin is very safe for human consumption because it has been part of the human diet for thousands of years. For example, a single serving of well pigmented wild salmon can contain 3 to 6 mg of pure astaxanthin. Numerous toxicity studies with astaxanthin extracts or astaxanthin rich alga meal of Haematococcus have not shown any serious adverse effects. Furthermore, clinical trials performed with astaxanthin rich alga meal with daily doses up to 40 mg astaxanthin lasting 4 weeks.
Since 1995, astaxanthin in the form of alga meal has been available as a food supplement in Scandinavia and astaxanthin extract products have also been marketed since 1999 with no reports of negative side effects.
Unique Production Systems
Fuji invested millions of dollars to cultivate natural microalgae called Haematococcus Pluvialis in Maui, Hawaii and Gustavsberg, Sweden in unique closed-bioreactor systems. These closed systems effectively stimulates the optimum conditions for astaxanthin production that yields the highest quality and minimises risk of contaminants. Fuji Chemical Industry adds value to the raw material ingredient by offering higher potencies and unmatched physical properties to suit your need for creating better products. Not all natural astaxanthin products are the same.
- Powerful Singlet Oxygen Quencher & Cell Membrane Protector
- Comparison of astaxanthin's singlet oxygen quenching activity with common antioxidants
- No Prooxidant or Vitamin A Activity
- Antioxidant Potency
Its unique chemical structure as a carotenoid with superior positioning and orientation in the cell membrane, it has been shown that it is:
- 75 times stronger than Alpha lipoic acid1
- 550 times stronger than Green tea catechins1
- 800 times stronger than CoQ101
- 6,000 times stronger than Vitamin C1
- 550 times stronger than Vitamin E (α-tocopherol)2
- 40 times stronger than Beta-Carotene3
- 17 times more potent than Grape Seed Extracts4
- Potent antiperoxidative membrane activity5
- Inhibits NF-κB inflammatory gene expression6
- Suppresses DNA damage (8-OHdG)7
- Ultimate Synergistic Protection
- Astaxanthin when combined with Lycopene shows significantly stronger oxidation resistance than when lycopene, lutein, or astaxanthin are taken alone8
- Various increases in antioxidant power are shown in combination with lipoic acid, resveratrol, ergothioneine, ascorbic acid, ginseng, garlic, ginko biloba9
- Tests results show better antioxidant protection in combination with tocotrienols10
- Ultimate Safety: Carotenoids & Pro-oxidation
- Astaxanthin has been classified as a "Pure Anti-oxidant" unlike certain other carotenoids such as β-carotene, lutein and lycopene that may show "Pro-oxidative" characteristics under certain conditions. This causes carotenoids to become a free radical that is capable of attacking the cells and constituents.11 Air pollution, exposure to ultraviolet light, radiation and smoking are also examples of pro-oxidants.
- Chemical Structure of Astaxanthin (free form)
AstaREAL® - For Dietary Supplements
- OIL:standardized astaxanthin oil extract with high potency. Ideal for blending as well as stand alone formulations.
- Powder:standardized astaxanthin powderized extract with excellent potency and powder properties. Ideal for blending, capsule filling or direct compression.
- Water soluble:Standardized astaxanthin emulsified extract with excellent water solubility. Ideal for functional beverages, food and liquid nutraceutical supplements.
AstaTROL® - For Cosmetics & Personal Care
- Standardized astaxanthin oil extract with additional processing steps to minimize odour.
- Nishida Y. et. al, Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants
against Singlet Oxygen Using Chemiluminescence Detection System. Carotenoid Science 11:16-20 (2007)
- Miki, W., Biological functions and activities of animal carotenoids. Pure and Appl. Chem. 1991; 63: 141-6.
- Shimizu, N., et al., Carotenoids as singlet oxygen quenchers in marine organisms. Fisheries Sci. 1996; 62: 134-7.
- Fuji Chemical Industry Co., Ltd., Outsourced test by Collaborative Labs, Setauket, NY 2001.
- Goto S. et al., Efficient Radical Trapping at the Surface and Inside the Phospholipid Membrane is Responsible for Highly Potent Antiperoxidative Activity of the Carotenoid Astaxanthin. Biochim Biophys Acta. 2001; 1512(2):251-8.
- Lee SJ. et al., Astaxanthin Inhibits Nitric Oxide Production and Inflammatory Gene Expression by Supressing IκB Kinase-dependent NF-κB Activation. Mol. Cells 2003; 16(1):97-105.
- Naito Y., et al., Prevention of Diabetic Nephropathy by Treatment with Astaxanthin in Diabetic db/db Mice. BioFactors 2004; 20:49-59.
- Lino et al., Kyoto 1991 ; In Japanese.
- Babish J.G., Composition Exhibiting Synergistic Antioxidant Activity US Patent Applied 2000.
- Babish J.G., Compositions Containing Carotenoids and Tocotrienols and having Synergistic Antioxidant Effect. US Patent Applied 2000.
- Martin, H. D. et al., Chemistry of carotenoid oxidation and free radical reactions. Pure Appl., 1999 71(12):2253-2262.